cyclo{[(6-Amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid)-(D-Phe)]2}

6-[Bis(ethoxycarbonyl)methyl]-6-deoxy-1,2;3,4-di-O-isopropyl­idene-d-galacto­pyran­ose

The title compound, C(19)H(30)O(9), was prepared by substitution at the C6 position in 1,2;3,4-di-O-isopropyl-idene-6-O-trifluoro-methane-sulfonyl-d-galactose using sodium eth-oxy-malonate in dimethyl-formamide. The conformation is skew-boat (0)S(2), slightly distorted towards boat B(2,5). The inflexible pyran-ose structure makes the title compound a suitable inter-mediate for further synthetic...

Preparation of 6-azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose.

6-Azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose (3) was synthesized from 6-azido-6-deoxycellulose (1) by two reaction steps. The myristoylation of compound 1 with myristoyl chloride/pyridine proceeded smoothly to give 6-azido-6-deoxy-2,3-di-O-myristoylcellulose (2) in 97.0% yield. The reaction of compound 2 with fullerene (C(60)) was carried out by microwave heating to afford compound 3 in h...

An ortho­rhom­bic polymorph of 6-de­oxy-6-iodo-1,2:3,4-di-O-isopropyl­idene-α-d-galactopyran­oside

The title compound, C(12)H(19)IO(5), is the ortho-rhom-bic polymorph of a previously reported monoclinic form [Krajewski et al. (1987 ▶). Bull. Pol. Acad. Sci. Chem.35, 91-102]. The dihedral angles between the six-membered ring and the two five-membered rings are 67.66 (14) and 71.79 (13)°, whereas the dihedral angle between the five-membered rings is 74.41 (12)°, indicating that all three ring...

Astudyon D-amino-acid Oxidase

Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.

D-Amino acids administered to animals are absorbed by the intestine and transported through the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase and D-aspartate oxidase to produce the same compounds they do in vitro; i.e. NH3, H2O2, and the keto acid corresponding to the amino acid ingested. In the liver and kidneys of the animals, an inverse relationship ex...